What Is Sperm Preparation in a Microfluidic Membrane Chamber?
Sperm preparation in a microfluidic membrane chamber is a modern and highly effective method for selecting high-quality sperm cells, used in assisted reproduction procedures. Its purpose is to obtain the healthiest possible sperm — with optimal motility, morphology, and genetic integrity — to increase the likelihood of successful fertilisation and healthy embryo development.
How Does the Microfluidic Membrane Method Work?
The microfluidic membrane chamber functions as an intelligent, biologically adapted filtration system. The method is based on the natural motility of sperm cells and their ability to move through fluid streams within the device’s microchannels, which mimic the conditions of the female reproductive tract.
As a result, only the most functional and high-quality sperm cells can pass through the membrane:
• with strong motility,
• with superior morphology,
• with a lower level of DNA fragmentation.
Why Is Sperm Preparation in a Microfluidic Membrane Chamber Necessary?
Higher quality of selected sperm
• The method helps isolate sperm with better motility and morphology — essential factors for successful fertilisation and embryo development.
Reduced risk of DNA damage
• Microfluidic filtration is particularly recommended when an elevated DNA fragmentation index is detected. Selected sperm typically show lower DNA damage, which may positively impact both conception and pregnancy progression.
A selection process closer to nature
• The method mimics the natural journey of sperm within the female reproductive system, allowing only the strongest cells to progress. This ensures a more biologically accurate selection compared to some mechanical methods.
Improved preparation for procedures
• Prior to sperm injection into the oocyte (ICSI), selecting the healthiest possible sperm is crucial. The microfluidic method enhances both the precision and safety of this selection.
Potential for improved treatment outcomes
• Higher-quality sperm can increase the chances of successful fertilisation and support the development of a healthy embryo.
The Microfluidic Membrane Method — A Step Closer to a Successful Pregnancy
By enabling the selection of only the best sperm cells, this method enhances the effectiveness of assisted reproduction and increases a couple’s chances of achieving the long-awaited pregnancy.
